Oncogene HST

**Semantic type:** Gene or Genome

**Definition:** Human Oncogene HST is a mutated variant of FGF4 Gene (FGF Family) about 35 kb downstream of INT2 (same orientation), which encodes Fibroblast Growth Factor 4, a heparin-binding growth factor with homology to basic and acidic FGF. Gremlin relays an SHH signal from the polarizing region to the apical ectodermal ridge. Formin-dependent activation of BMP-antagonist Gremlin induces FGF4 and the SHH/FGF4 feedback loop. Oncogene HST disrupts normal cell function.

**Synonyms:** - FGF4 - FGF4 Oncogene - Fibroblast Growth Factor 4 Oncogene - HSTF1 - Human Stomach Cancer Derived Oncogene - K-FGF - Kaposi Sarcoma Oncogene