Suramin Sodium

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis.

**Synonyms:** - 309 F - 309 F - 8,8'-(Carbonylbis(imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino))bis-1,3,5-naphthalenetrisulfonic Acid Hexasodium Salt - Antrypol - Antrypol - Bayer 205 - Bayer 205 - Belganyl - CI-1003 - Fourneau 309 - Fourneau 309 - Germanin - Germanin - Metaret - Moranyl - Moranyl - Naganin - Naganin - Naganinum - Naganol - Naganol - Naphuride - SURAMIN SODIUM - Sodium Suramin - Sodium suramin - Suramin Hexasodium - Suramin Hexasodium - Suramin sodium