Donor-derived Haploidentical IL-21-Expanded Natural Killer Cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A population of ex-vivo human interleukin-21 (IL-21) expanded donor-derived human leukocyte antigen (HLA) haploidentical natural killer (haploNK) cells, with potential immunomodulating and antineoplastic activities. Upon administration in patients undergoing HLA-haploidentical hematopoietic cell transplantation, the donor-derived haploidentical IL-21-expanded NK cells target, lyse and destroy tumor cells. IL-21 promotes sustained ex vivo proliferation of human NK cells and enhances its cytotoxic activity.

**Synonyms:** - Allogeneic IL-21-expanded haploNKs - Donor-derived Haploidentical IL-21-Expanded NKs - Donor-derived IL-21 Expanded NK Cells - IL-21-treated HLA-haploidentical Donor NK Cells