Edaxeterkib

**Semantic type:** Pharmacologic Substance

**Definition:** An inhibitor of the extracellular signal-regulated kinases (ERK) 1 and 2, with potential antineoplastic activity. Upon intravenous administration, edaxeterkib specifically binds to and inhibits both ERK 1 and 2, thereby preventing the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The MAPK/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in the proliferation, differentiation and survival of tumor cells.

**Synonyms:** - EDAXETERKIB - ERK Inhibitor KO-947 - ERK1/2 Inhibitor KO-947 - Extracellular Signal-regulated Kinase 1/2 Inhibitor KO-947 - KO 947 - KO-947 - KO947