ErbB Receptor Family Protein

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme|Receptor

**Definition:** A family of cellular proteins encoded by the c-erbB genes, including epidermal growth factor receptor. They are normally expressed in a variety of tissues of epithelial, mesenchymal, and neuronal origin. They are overexpressed in a significant portion of adenocarcinomas found at various sites, especially in the breast. Gene amplification appears to be the predominant method leading to overexpression.

**Synonyms:** - EGF Receptor Family - EGF Receptor-Tyrosine Kinase Family - EGFR Family - ERBB Family - ERBB Receptor-Tyrosine Kinase Family - Epidermal Growth Factor Receptor Family - ErbB Receptor Tyrosine Kinase Family - HER Family - HER Family Receptor - Human Epidermal Growth Factor Receptor Family - erbB Receptor Family