BCL1 Oncogene

**Semantic type:** Gene or Genome

**Definition:** Human cyclin D1 (BCL1) proto-oncogene, located at 11q13, encodes G1/S-specific cyclin D1 (CCND1) protein. BCL1 gene expression is activated in human B-cell lymphomas by translocation, t(11;14)(q13;q32), with immunoglobulin gene regions. Enhanced expression of cyclin D1 protein has also been detected in parathyroid adenomas due to a translocation, t(11;11)(q13;p15), resulting in fusion of BCL1 with the parathyroid hormone enhancer.

**Synonyms:** - B-Cell Chronic Lymphocytic Leukemia Associated Oncogene - B-cell Leukemia 1 - BCL