Ibentatug

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A humanized monoclonal antibody directed against human plectin (plectin-1; plectin 1), with potential antineoplastic activity. Upon administration, ibentatug specifically binds to plectin expressed on the cell surface of cancer cells, thereby activating the immune system to induce an anti-tumor T-cell response against plectin-expressing cancer cells and inducing apoptosis in these cancer cells. Plectin, a pro-tumorigenic protein, is normally found inside the cytoplasm of healthy cells but is only selectively expressed on the cell surface of various cancer cells. Cancer-specific plectin (CSP), also known as cell surface plectin-1 (CSP1), plays an important role in cancer cell proliferation, migration and invasion.

**Synonyms:** - Anti-CSP Monoclonal Antibody ZB131 - Anti-CSP1 Monoclonal Antibody ZB131 - Anti-cancer-specific Plectin Monoclonal Antibody ZB131 - Anti-cell Surface Plectin 1 Monoclonal Antibody ZB131 - Anti-cell Surface Plectin-1 Monoclonal Antibody ZB131 - Anti-plectin Monoclonal Antibody ZB131 - Anti-plectin-1 Monoclonal Antibody ZB131 - IBENTATUG - ZB 131 - ZB-131 - ZB131