Plozalizumab Plevistinag

**Semantic type:** Pharmacologic Substance

**Definition:** An antibody-drug conjugate (ADC) composed of plozalizumab, a humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against the human C-C chemokine receptor 2 (CCR2), conjugated to TAK-676, an agonist for the stimulator of interferon genes (STING; transmembrane protein 173; TMEM173), with potential immuno-activating and antineoplastic activities. Upon intravenous administration, plozalizumab plevistinag targets and binds to CCR2, which prevents binding of the endothelium-derived CLL2 (monocyte chemoattractant protein-1 or MCP1) to its receptor CCR2. This prevents CCR2-mediated signaling and may lead to an inhibition of recruitment of inflammatory cells. This may inhibit inflammation, angiogenesis, tumor cell migration, and tumor cell proliferation. In addition, the activation of STING pathway by TAK-676 in immune cells in the tumor microenvironment (TME) leads to the production of pro-inflammatory cytokines, including interferons (IFNs), enhances the cross-presentation of tumor-associated antigens (TAAs) by dendritic cells (DCs), and induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. STING, a transmembrane protein that activates immune cells in the TME, plays a key role in the activation of the innate immune system. The conjugation of the antibody to TAK-676 improves targeted delivery of the STNG agonist and increases tumor exposure to TAK-676 and enhances the STING-mediated anti-tumor immune responses. The G-protein coupled receptor CCR2 is expressed on the surface of monocytes and macrophages, stimulates the migration and infiltration of these cell types, and plays an important role in inflammation, angiogenesis, and tumor cell migration and proliferation.

**Synonyms:** - ADC STING Agonist TAK-500 - ADC TAK-500 - Antibody STING Drug Conjugate TAK-500 - Antibody-drug Conjugate TAK-500 - PLOZALIZUMAB PLEVISTINAG - STING ADC TAK-500 - Stimulator of Interferon Genes Agonist TAK-500 - TAK 500 - TAK-500 - TAK500