Plasma Cell Myeloma-Induced Bone Disease

**Semantic type:** Neoplastic Process

**Definition:** Bone infiltration by malignant plasma cells in patients with history of plasma cell myeloma. Bone involvement occurs in approximately eighty percent of newly diagnosed symptomatic plasma cell myeloma patients. The axial skeleton, particularly the spine, and the proximal long bones are the most commonly affected bone sites. It results in osteolytic bone lesions, widespread osteopenia, and compression fractures.

**Synonyms:** - MBD - Multiple Myeloma-Induced Bone Disease - Myeloma Bone Disease