MYB/QKI Fusion Protein

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** A fusion protein encoded by the MYB/QKI fusion gene. This protein is comprised of the N-terminus of transcriptional activator Myb protein, including the helix-turn-helix (HTH)-type DNA binding domain and the transactivation domain (long variants resulting from fusions including exon 15 of the MYB gene also have a C-terminal negative regulatory domain), which is fused to the amino acids comprising the C-terminal half of protein quaking, which excludes the RNA binding KH domain but includes the QUA2 RNA binding and SH3-binding domains (both the long and short variants of this fusion protein may also include the QKI C-terminal nuclear localization sequence (NLS)).

**Synonyms:** - MYB-QKI Fusion Protein - MYB::QKI Fusion Protein - Transcriptional Activator Myb-Protein Quaking Fusion Protein - Transcriptional Activator Myb/Protein Quaking Fusion Protein