Pegfilgrastim

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A long-acting pegylated form of a recombinant therapeutic agent which is chemically identical to or similar to an endogenous human granulocyte colony-stimulating factor (G-CSF). Produced endogenously by monocytes, fibroblasts, and endothelial cells, G-CSF binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. Conjugation of the cytokine with a branched polyethylene glycol molecule (pegylation) significantly increases its therapeutic half-life. (NCI04)

**Synonyms:** - Dulastin - Filgrastim SD-01 - Fulphila - Fylnetra - G-Lasta - HSP-130 - Jinyouli - Neulasta - Neulasta - Neulastim - Neupopeg - Nyvepria - PEG-filgrastim - PEGFILGRASTIM - PF-06881894 - Pegcyte - Pegfilgrastim Biosimilar HSP-130 - Pegfilgrastim Biosimilar Nyvepria - Pegfilgrastim Biosimilar PF-06881894 - Pegfilgrastim Biosimilar Pegcyte - Pegfilgrastim Biosimilar Udenyca - Pegfilgrastim Biosimilar Ziextenzo - Pegfilgrastim-apgf - Pegfilgrastim-bmez - Pegfilgrastim-cbqv - Pegfilgrastim-fpgk - Pegfilgrastim-fpgk - Pegfilgrastim-jmdb - Pegfilgrastim-jmdb - Pegfilgrastim-pbbk - Pegfilgrastim-pbbk - Pegylated G-CSF - Pegylated GCSF - Pegylated Granulocyte Colony Stimulating Factor - SD-01 - SD-01 sustained duration G-CSF - Stimufend - Tripegfilgrastim - Udenyca - Ziextenzo - filgrastim-SD/01 - pegfilgrastim - pegfilgrastim-apgf - pegfilgrastim-bmez - pegfilgrastim-cbqv