Pediatric Glioma RTK2 Molecular Signature Detected

**Semantic type:** Laboratory or Test Result

**Definition:** An indication that the RTK2-type molecular signature for pediatric high grade glioma was detected in a sample. This signature occurs more frequently in supratentorial than infratentorial gliomas and co-occurs with expression of both wild-type histone H3 and wild-type IDH. The RTK2-type molecular signature is characterized by the following molecular abnormalities (in order of most to least frequent) homozygous deletion of chromosome 9p, TERT promoter mutation, EGFR gene amplification, TP53 gene mutation, loss of chromosome 10q, gain of chromosome 7 and CDK4/6 mutations. This signature may rarely include MYCN gene amplification and PDGFRA gene amplification. Additionally, MGMT promoter methylation and loss of ATRX protein expression are not characteristics of this signature.

**Synonyms:** - pedGBM_RTK2 Signature Detected