Hemoglobin Beta Heterozygous Insufficiency Plus Null Genotype

**Semantic type:** Laboratory or Test Result

**Definition:** A genetic finding indicating that one copy of chromosome 16 has a hemoglobin beta gene (HBB) with mutations that lead to hemoglobin subunit beta insufficiency (B+) and the other copy has HBB loss of function or gene deletion mutations (B0). This genotype is associated with beta thalassemia intermedia.

**Synonyms:** - (B+/B0) - (B0/B+) - B+/B0 - B0/B+ - HBB Heterozygous Null with Insufficiency - beta-globin genotype (B+/B0)