GCN2 Activator HC-7366-K

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An immediate release (IR) capsule formulation of the potassium salt monohydrate form of HC-7366, an activator of the serine/threonine protein kinase general control nonderepressible 2 (GCN2), with potential antineoplastic and immunomodulating activities. Upon oral administration, the base moiety HC-7366 of the GCN2 activator HC-7366-K targets and binds to, and activates GCN2, which phosphorylates eukaryotic translation initiation factor 2A (eIF2A), thereby inducing cyclic AMP-dependent transcription factor ATF-4 transcription and ATF-4-mediated integrated stress response (ISR). This may result in apoptosis. GCN2 plays a key role in the activation of the ISR pathway in response to amino acid deprivation and in hypoxic tumors. While ISR promotes the adaptation of tumor cells to hypoxic stress, prolonged activation of ISR induces apoptosis.

**Synonyms:** - GCN2 Activator HC-7366 Potassium IR Formulation - General Control Nonderepressible 2 Activator HC-7366-K - HC 7366-K - HC-7366 Potassium Immediate Release Formulation - HC-7366 Potassium Monohydrate - HC-7366-K - HC7366-K