RB1 Cell Cycle Pathway Deregulation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** Deregulation of the RB1 cell cycle pathway leads to unregulated DNA replication and cell proliferation, which is usually associated with activating mutations in cyclin-dependent kinase genes or inactivating mutations in either cyclin-dependent kinase inhibitor genes or the retinoblastoma gene.

**Synonyms:** - Retinoblastoma Tumor Suppressor Protein Cell-Cycle Pathway Deregulation