Anti-CD20/anti-CD3 Bispecific Antibody CM355

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A bispecific antibody and novel T cell engager1 (nTCE) targeting both the tumor-associated antigen (TAA) CD20 and the CD3, a T-cell surface antigen, with potential immunomodulating and antineoplastic activities. Upon administration, anti-cd20/anti-cd3 bispecific antibody CM355 binds to both T-cells and CD20-expressing B-lineage tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against the CD20-expressing tumor B-cells. CD20 is exclusively expressed on B-cells during most stages of B-cell development and is often overexpressed in B-cell malignancies.

**Synonyms:** - Anti-CD20/CD3 Bispecific Antibody CM355 - CD20/CD3 Bispecific Antibody CM355 - CD20xCD3 Bispecific Antibody CM355 - CM 355 - CM-355 - CM355