Selective Estrogen Receptor Degrader AND019

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, SERD AND019 specifically targets and binds to the estrogen receptor (ER) and induces a conformational change that results in ER degradation. This prevents ER-mediated signaling and inhibits both the growth and survival of ER-expressing cancer cells.

**Synonyms:** - AND 019 - AND-019 - AND019 - SERD AND019