Oncolytic Adenovirus Expressing Interferon YSCH-01

**Semantic type:** Pharmacologic Substance

**Definition:** An oncolytic adenovirus that has been genetically engineered to express interferon (IFN), with potential immunostimulating and antineoplastic activities. Upon intratumoral administration, the oncolytic adenovirus expressing IFN YSCH-01 selectively infects and replicates in tumor cells, leading to tumor cell lysis. In addition, tumor cell lysis releases a variety of tumor-associated antigens (TAAs), which may potentially result in the activation of a systemic immune response against the TAAs-expressing tumor cells. The IFN expressed by the oncolytic adenovirus also activates T-lymphocytes, dendritic cells (DCs) and natural killer (NK) cells and induces an anti-tumor immune response against the tumor cells.

**Synonyms:** - Oncolytic Adenovirus Expressing IFN YSCH-01 - Oncolytic Adenovirus YSCH-01 - Oncolytic Virus YSCH-01 - Recombinant Oncolytic Adenovirus L-IFN YSCH-01 - YSCH 01 - YSCH-01 - YSCH01