Anti-EGFRvIII/CD3 Bispecific Antibody RO7428731

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A bispecific antibody directed against both a mutant form of the human epidermal growth factor receptor (EGFR), EGFR variant III (EGFRvIII), and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-EGFRvIII/CD3 bispecific antibody RO7428731 specifically binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and EGFRvIII on EGFRvIII-expressing tumor cells. This crosslinks T-cells and tumor cells, and activates and redirects CTLs to EGFRvIII-expressing tumor cells. This leads to CTL-mediated killing of EGFRvIII-expressing tumor cells. EGFRvIII, a mutant form of EGFR expressed in certain tumor cell types and frequently seen in malignant glioma, plays a key role in tumor cell proliferation and survival.

**Synonyms:** - Anti-EGFRvIII/Anti-CD3 Bispecific Antibody RO7428731 - EGFRvIII x CD3 Bispecific Antibody RO7428731 - RG 6156 - RG-6156 - RG6156 - RO 7428731 - RO-7428731 - RO7428731