Spinal Cord Ependymoma, MYCN Amplified

**Semantic type:** Neoplastic Process

**Definition:** A rare, aggressive ependymoma that arises from the spinal cord. It displays microvascular proliferation, necrosis, and high mitotic rate. It is characterized by high-level MYCN amplification. Cytogenetic abnormalities include loss of chromosome 10 and focal losses on chromosome 11q. The prognosis is poor.

**Synonyms:** - Spinal Cord Ependymoma, MYCN-Amplified - Spinal Ependymoma, MYCN Amplified - Spinal Ependymoma, MYCN-Amplified