Cytotoxic Chemotherapeutic Agent

**Semantic type:** Chemical Viewed Functionally

**Definition:** Any chemotherapeutic agent that is cytotoxic in nature and non-specifically kills rapidly proliferating cells, including tumor cells. This includes cytotoxic agents that are modified or formulated in such a way as to more specifically target tumor cells but for which the fundamental cytotoxic mechanism of action (MoA) has not changed. Targeted therapy agents that have antineoplastic MoAs are not included.

**Synonyms:** - Antineoplastic Cytotoxic Agent - Cytotoxic Antineoplastic Agent - Cytotoxic Chemotherapy Agent