Autologous Anti-CD7 CAR T Cells PA3-17

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) directed against the tumor-associated antigen (TAA) CD7, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous anti-CD7 CAR T-cells PA3-17 specifically recognize and bind to CD7-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas.

**Synonyms:** - Autologous CD7-CAR T-cells PA3-17 - Autologous CD7-CAR-T Cells PA3-17 - Autologous CD7-targeted CAR-T Cells PA3-17 - PA3 17 - PA3-17 - PA317