Germline DICER1 Loss of Function Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the DICER1 gene that originates in the gametes and either inhibits expression or results in the translation of an inactive endoribonuclease Dicer protein.

**Synonyms:** - Germline DCR1 Loss of Function Gene Mutation - Germline DICER Loss of Function Gene Mutation - Germline Dicer 1, Ribonuclease III Loss of Function Gene Mutation - Germline HERNA Loss of Function Gene Mutation - Germline Inactivating DICER1 Gene Mutation - Germline Inactivating DICER1 Mutation - Germline MNG1 Loss of Function Gene Mutation - Germline RMSE2 Loss of Function Gene Mutation