Autologous Anti-FSHR CER-4-1BB/CD3zeta-expressing T-lymphocytes

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous human T-lymphocytes genetically modified to express a chimeric endocrine receptor (CER) targeting the human follicle stimulating hormone receptor (FSHR) and coupled to the signaling domains of 4-1BB (CD137) and CD3 zeta, with potential immunostimulatory and antineoplastic activities. Upon administration, the autologous anti-FSHR CER-4-1BB/CD3zeta-expressing T-lymphocytes target and bind to the FSHR on FSHR-expressing tumor cell surfaces, thereby killing FSHR-expressing tumor cells. FSHR is not normally expressed in healthy non-ovarian tissue, but is present on several types of ovarian, fallopian tube, or primary peritoneal cancers.

**Synonyms:** - Autologous Anti-FSHR Chimeric Endocrine Receptor-expressing T Cells - Autologous FSHCER T Cells - Autologous FSHR-specific 4-1BB/CD3zeta CER T-cells - Autologous Follicle Stimulating Hormone Receptor-targeting Chimeric Endocrine Receptor T Cells