Autologous MUC1-activated T-cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous T-lymphocytes that have been activated against the tumor associated antigen (TAA) mucin-1 (MUC1), with potential immunomodulating and antineoplastic activities. Upon re-introduction into the patient, autologous MUC1-activated T-cells specifically recognize and induce selective toxicity in MUC1-expressing tumor cells. MUC1, a glycoprotein overexpressed on the surface of a variety of cancer cells, plays a key role in tumor cell survival and proliferation.

**Synonyms:** - Autologous MUC1-activated T-lymphocytes