Vatalanib

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An orally bioavailable anilinophthalazine with potential antineoplastic activity. Vatalanib binds to and inhibits the protein kinase domain of vascular endothelial growth factor receptors 1 and 2; both receptor tyrosine kinases are involved in angiogenesis. This agent also binds to and inhibits related receptor tyrosine kinases, including platelet-derived growth factor (PDGF) receptor, c-Kit, and c-Fms.

**Synonyms:** - CGP 79787 - CGP-79787 - N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine - PTK787 - PTK787/ZK 222584 - VATALANIB - ZK-232934 - vatalanib