Valdecoxib

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A sulfonamide derivative and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities. Valdecoxib selectively binds to and inhibits cyclooxygenase (COX)-2, thereby preventing the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and therefore does not interfere with blood coagulation.

**Synonyms:** - 4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide - 4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide - Bextra - SC 65872 - VALDECOXIB - valdecoxib