GPR31 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human GPR31 wild-type allele is located in the vicinity of 6q27 and is approximately 3 kb in length. This allele, which encodes 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor protein, plays a role in lipid-dependent G protein-coupled receptor signaling. This gene plays a role in membrane localization of an alternatively spliced variant of KRAS, KRAS4B, which is associated with proliferation, survival and macropinocytosis of tumor cells in KRAS-dependent cancers.

**Synonyms:** - 12-(S)-HETE Acid Receptor Gene - 12-(S)-Hydroxy-5,8,10,14-Eicosatetraenoic Acid (HETE) Receptor Gene - 12-HETER - BA517H2.2 (G Protein-Coupled Receptor 31) Gene - G Protein-Coupled Receptor 31 wt Allele - G-Protein Coupled Receptor 31 Gene - HETER - HETER1 - Hydroxyeicosatetraenoic (HETE) Acid Receptor 1 Gene