Copper Cu 64 Abefolastat Tesaroxetan

**Semantic type:** Pharmacologic Substance

**Definition:** A radioconjugate composed of abefolastat tesaroxetan, two human prostate-specific membrane antigen (PSMA) binding motifs linked to a SAR chelator, and labeled with the positron emission tomography (PET) tracer copper Cu 64, with potential use as a tracer for PSMA-expressing tumors during positron emission tomography (PET)/computed tomography (CT). Upon administration of copper Cu 64 abefolastat tesaroxetan, the PSMA binding motifs target and bind to PSMA-expressing tumor cells. Upon binding, PSMA-expressing tumor cells can be detected during PET/CT imaging. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells.

**Synonyms:** - 64Cu SAR-bisPSMA - 64Cu-SAR-bisPSMA - ABEFOLASTAT TESAROXETAN CU-64 - Copper Cu 64 SAR-bisPSMA - Copper Cu 64-SAR-bisPSMA - SAR-Bis-PSMA Cu-64