EGFR Inhibitor NRC-2694 Dihydrochloride

**Semantic type:** Pharmacologic Substance

**Definition:** The dihydrochloride salt form of NRC-2694, an orally bioavailable, small-molecule inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, EGFR inhibitor NRC-2694 binds to and inhibits EGFR, which prevents EGFR-mediated signaling and leads to cell death in EGFR-expressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.

**Synonyms:** - NRC-2694 DIHYDROCHLORIDE - NRC-2694-B - NRC-2694B