Nasaruplase Gamma

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme|Pharmacologic Substance

**Definition:** A proenzyme and recombinant form of single-chain human urokinase plasminogen activator (scuPA), with potential intrapleural fibrinolytic and draining-promoting activities in certain lung conditions such as complicated parapneumonic pleural effusion (CPE) and empyema. After intrapleural administration, nasaruplase gamma is converted into uPA. uPA breaks down the fibrinous adhesions and promotes the draining of pleural fluid around the lungs in non-draining loculated pleural effusions (LPE). This may reduce LPE-associated complications, such as pain, shortness of breath, pleural infections, and sepsis.

**Synonyms:** - LTI 01 - LTI-01 - LTI01 - NASARUPLASE GAMMA - Recombinant Single-chain Urokinase Plasminogen Activator LTI-01 - Zymogen LTI-01 - scuPA LTI-01