Anti-BAFFR Monoclonal Antibody ESG206

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A monoclonal antibody that is directed against the tumor-associated antigen (TAA) B-cell activating factor receptor (BAFFR; tumor necrosis factor receptor superfamily member 13C; TNFRSF13C; BLyS receptor 3; BR3), with potential antineoplastic activity. Upon administration, anti-BAFFR monoclonal antibody ESG206 binds to and blocks BAFFR. This prevents BAFFR-mediated signaling and may kill BAFFR-expressing tumor cells. BAFFR, a protein belonging to the TNF receptor superfamily, is expressed on the surface of certain types of cancer cells, including B-cell acute lymphoblastic leukemia. It plays a key role in the regulation of peripheral B-cell survival.

**Synonyms:** - ESG 206 - ESG-206 - ESG206