EBP Inhibitor DSP-0390

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable inhibitor of emopamil-binding protein (EBP), with potential antineoplastic activity. Upon oral administration, EBP inhibitor DSP-0390 targets, binds to and inhibits the activity of EBP. This inhibits EBP-mediated de novo cholesterol synthesis. As cholesterol is essential for tumor cell proliferation and survival, this inhibits tumor cell proliferation. The inhibition of EBP also results in the accumulation of its substrates zymostenol and zymosterol, and autophagy in tumor cells. EBP, a non-glycosylated type I integral membrane protein of endoplasmic reticulum, plays an important role in cholesterol biosynthesis, autophagy and oligodendrocyte formation, and is overexpressed in certain tumors.

**Synonyms:** - DSP 0390 - DSP-0390 - DSP-0390 - DSP0390 - Emopamil-binding Protein Inhibitor DSP-0390