Midostaurin

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic indolocarbazole multikinase inhibitor with potential antiangiogenic and antineoplastic activities. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platelet-derived growth factor receptor (PDGFR) and FMS-like tyrosine kinase 3 (FLT3) tyrosine kinases, which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors.

**Synonyms:** - CGP 41251 - CGP41251 - MIDOSTAURIN - N-Benzoyl-Staurosporine - N-Benzoylstaurosporine - N-benzoyl-staurosporine - PKC 412 - PKC-412 - PKC412 - PKC412 - Rydapt - midostaurin