Mount Sinai Acute Graft Versus Host Disease International Consortium Grade III

**Semantic type:** Classification

**Definition:** Acute graft-versus-host disease (GVHD) that presents with stage 2 (bilirubin 3.1-6 mg/dL) or stage 3 (bilirubin 6.1-15 mg/dL) liver involvement; and/or stage 2 (1000-1500 mL stools/day or five to seven bowel movements/day (adults) or 20-30 mL stools/kg/day or seven to ten bowel movements/day (children)) or stage 3 (>1500 mL stools/day or more than seven bowel movements/day (adults) or >30 mL stools/kg/day or more than ten bowel movements/day (children)) lower gastrointestinal tract involvement; and with stage 0 (no active erythematous GVHD rash), stage 1 (maculopapular rash <25% of body surface area), stage 2 (maculopapular rash 25-50% of body surface area), or stage 3 (maculopapular rash >50% of body surface area) skin involvement; and/or stage 0 (no or intermittent nausea, vomiting or anorexia) or stage 1 (persistent nausea, vomiting or anorexia) upper gastrointestinal tract involvement.

**Synonyms:** - Graft Versus Host Disease Grade III - MAGIC Grade III