Mount Sinai Acute Graft Versus Host Disease International Consortium Grade IV

**Semantic type:** Classification

**Definition:** Acute graft-versus-host disease (GVHD) that presents with stage 4 (generalized erythroderma (>50% of body surface area) plus bullous formation and desquamation >5% of body surface area) skin involvement; stage 4 (bilirubin >15 mg/dL) liver involvement; or stage 4 (severe abdominal pain with or without ileus, or grossly bloody stool regardless of volume) lower gastrointestinal tract involvement; with stage 0 (no or intermittent nausea, vomiting or anorexia) or stage 1 (persistent nausea, vomiting or anorexia) upper gastrointestinal tract involvement.

**Synonyms:** - Graft Versus Host Disease Grade IV - MAGIC Grade IV