Autologous HBV-specific TCR-expressing T-lymphocytes SCG101

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of human autologous T-lymphocytes transduced with a retroviral vector encoding for a T-cell receptor (TCR) specific for HLA-A*02-restricted human hepatitis B virus (HBV) surface antigen (HBsAg) peptide, with potential antineoplastic activity. Upon administration, the autologous HBV-specific TCR-expressing T-lymphocytes SCG101 recognize and bind to HBV antigen-positive cells, which induces cytotoxic T-lymphocyte (CTL)-mediated elimination of HBV antigen-positive cells, including those in HBV-related hepatocellular carcinoma (HCC).

**Synonyms:** - Autologous HBV-specific T-cell Receptor-expressing T-lymphocytes SCG101 - Autologous HBV-specific TCR-T Cells SCG101 - SCG 101 - SCG-101 - SCG101