TEAD Transcription Factor Family

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** A family of transcription factors that play important roles during development, cell proliferation, regeneration, and tissue homeostasis as members of various signal transduction pathways including Hippo, Wnt, transforming growth factor beta (TGFB), and epidermal growth factor receptor (EGFR) pathways. Members of the family have an N-terminal DNA-binding region of about 66 to 68 amino acids, which is named for the two proteins that originally defined the domain: TEF-1 and abaA (TEA domain or TEAD), and a C-terminal region YAP binding domain (YBD) that binds to the transcriptional coactivators of the Hippo signaling pathway, YAP1 and WWTR1(TAZ).

**Synonyms:** - TEA Domain Family - TEA Domain Transcription Factor - TEA Domain Transcription Factor Family - TEAD Family - TEAD Transcription Factor