Dominant-Negative Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** Any mutation that encodes an altered gene product that acts to antagonize the wild-type allele. Dominant negative mutations are characterized by a dominant or semi-dominant phenotype, and usually result in loss of function.

**Synonyms:** - Dominant Negative - Dominant-Negative Mutant - Dominant-Negative Mutation Abnormality