Anti-CD19-CAR CMV-specific T-lymphocytes

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of human cytomegalovirus (CMV)-specific T-lymphocytes that have been engineered to express a chimeric antigen receptor (CAR) specific for the human tumor associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19-CAR CMV-specific T-lymphocytes recognize, bind to, and induce selective toxicity in CD19-expressing tumor cells. CD19 is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies. The anti-CD19-CAR CMV-specific T-lymphocytes may potentially be expanded in vivo through CMV vaccination.

**Synonyms:** - Anti-CD19-CAR CMV-specific T-cells - CMV-specific CD19 CAR-T Cells - CMV-specific CD19-CAR T Cells