Autologous PD-1-knockout Tumor-infiltrating Lymphocytes IOV-4001

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous tumor-infiltrating lymphocytes (TILs) where the programmed cell death protein 1 (PD-1; PDCD1; CD279; programmed death-1) gene has been disrupted using transcription activator-like effector nuclease (TALEN), with potential immunomodulating and antineoplastic activities. The autologous TILs are isolated from an autologous tumor sample, expanded ex-vivo and genetically modified to inactivate PD-1. Upon administration, the autologous PD-1-knockout TILs IOV-4001 induce a T-cell-mediated immune response against tumor cells. Expression of PD-1, an inhibitory receptor expressed on activated T-cells, plays a key role in cytotoxic T-lymphocyte (CTL) suppression, T-cell exhaustion and CTL apoptosis. PD-1 knockout may abrogate T-cell exhaustion and increase T-cell activity and cytotoxicity.

**Synonyms:** - Autologous PD-1-knockout TILs IOV-4001 - Autologous PDCD1 KO TILs IOV-4001 - Autologous PDCD1-knockout TILs IOV-4001 - Autologous PDCD1-knockout Tumor-infiltrating Lymphocytes IOV-4001 - IOV 4001 - IOV-4001 - IOV4001