Donor TCR Alpha/Beta/CD19-depleted Mononuclear Cell-enriched Activated Natural Killer Cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of donor-derived, haploidentical, cytokine-activated natural killer (NK) cells enriched with mononuclear cells from haploidentical donor that have been depleted of T-cell receptor (TCR) alpha and beta (TCRa/b+) as well as CD19-positive (CD19+) cells, that may potentially be used for immune reconstitution purposes. Upon administration, the donor TCR alpha/beta/CD19-depleted mononuclear cell-enriched activated NK cells may enhance immune reconstitution. The depletion of alpha/beta T-cells, which are implicated in the adaptive immune response that mediates graft-versus-host disease (GvHD), may promote rapid and sustained engraftment, immune reconstitution, and may prevent or reduce the development of GvHD. The depletion of CD19+ B-cells may reduce the risk of Epstein-Barr virus (EBV)-driven post-transplant lymphoproliferative disorders.

**Synonyms:** - Allogeneic TCR Alpha/Beta/CD19-depleted Mononuclear Cell-enriched Activated NK Cells - Donor TCR Alpha/Beta/CD19-depleted Mononuclear Cell-enriched Activated NK Cells - TCR AlphaBeta/CD19-depleted DEA-NK Cells - TCR AlphaBeta/CD19-depleted Donor Enriched Activated Natural Killer Cells