Cathepsin-targeted Fluorescent Imaging Probe VGT-309

**Semantic type:** Pharmacologic Substance

**Definition:** A fluorescently quenched, cathepsin-activatable, near infrared (NIR) probe containing the dye indocyanine green (ICG), that may be used for cancer imaging purposes using an NIR imaging system. Upon administration, cathepsin-targeted fluorescent imaging probe VGT-309 covalently and irreversibly binds to cathepsins overexpressed by tumor cells. This displaces the quencher QC-1 and activates the ICG fluorophore. Upon NIR imaging, cathepsin-expressing tumor cells can be detected which allows for visualization of the tumor.

**Synonyms:** - Cathepsin-activatable Fluorescent Imaging Agent VGT-309 - Cathepsin-targeted Fluorescent Imaging Agent VGT-309 - VGT 309 - VGT-309 - VGT309