Autologous Anti-CD19 CAR-expressing T-lymphocytes UF-KURE19

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous T-lymphocytes that have been genetically modified and transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) that targets the human tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR-expressing T-lymphocytes UF-KURE19 bind to and induce selective toxicity against CD19-expressing tumor cells. The CD19 antigen is a B-cell-specific cell surface antigen expressed in all B-cell lineage malignancies.

**Synonyms:** - Autologous Anti-CD19 CAR T Cells UF-KURE19 - Autologous Anti-CD19 CAR T-cells UF-KURE19 - UF KURE19 - UF-KURE19 - UF-KURE19 CAR-T Cells - UFKURE19