Encequidar Mesylate

**Semantic type:** Pharmacologic Substance

**Definition:** The mesylate form of encequidar, an inhibitor of the adenosine triphosphate (ATP)-binding cassette (ABC) transporter P-glycoprotein (P-gp), with adjuvant activity. Upon oral administration, encequidar selectively binds to and inhibits the multidrug resistance (MDR) efflux pump P-gp, which prevents the efflux of various chemotherapeutic agents from intestinal epithelial cells to the gastrointestinal tract. This leads to an increase in both oral bioavailability and therapeutic efficacy. P-gp prevents the intestinal uptake and intracellular accumulation of various cytotoxic agents. Encequidar is not systemically absorbed.

**Synonyms:** - 4H-1-Benzopyran-2-Carboxamide, N-(2-(2-(4-(2-(3,4-Dihydro-6,7-Dimethoxy-2(1H)-Isoquinolinyl)ethyl)phenyl)-2H-Tetrazol-5-yl)-4,5-Dimethoxyphenyl)-4-Oxo-, Methanesulfonate, Hydrate (1:1:1) - ENCEQUIDAR MESYLATE - Encequidar Mesylate Monohydrate - HM-30181 Methanesulfonate Monohydrate - HM30181 Mesylate Monohydrate - HM30181A