Vitamin D3 Analogue ILX23-7553

**Semantic type:** Pharmacologic Substance

**Definition:** A vitamin D3 analogue with potential antineoplastic activity. ILX23-7553 binds to and activates the vitamin D receptor, a cytoplasmic polypeptide expressed in normal vitamin D responsive tissues, but also overexpressed in certain cancers including hepatocellular carcinoma and pancreatic cancer. Mediated through vitamin D receptor, this agent induces cancer cell differentiation, inhibits cancer cell growth and induces apoptosis. In addition, ILX23-7553 may also induce growth arrest and apoptosis independent of vitamin D receptor activation through mechanisms that are not fully elucidated.

**Synonyms:** - 1,25-dihydroxy-16-ene-23-yne-cholecalciferol - 16-23-D3 - 9,10-Secocholesta-5,7,10(19),16-tetraen-23-yne-1,3,25-triol, (1alpha,3beta,5Z,7E)- - BXL 353 - ILEX 23-7553 - ILX 237553 - ILX-237553 - ILX23-7553 - ILX23-7553 - ILX237553 - RO 237553 - RO-23-7553 - RO-237553 - RO237553 - Ro23-7553