Anti-CD19/CD28 Bispecific Antibody RO7443904

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A bispecific antibody directed against both the tumor-associated antigen (TAA) CD19 and the co-stimulatory T-cell-specific surface glycoprotein CD28, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19/CD28 bispecific antibody RO7443904 targets and binds to both CD28 expressed on T-cells and CD19 expressed on tumor cells, which crosslinks the T-cells to the tumor cells. This may result in a potent cytotoxic T-lymphocyte (CTL) response against the CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies.

**Synonyms:** - Anti-CD19/Anti-CD28 Bispecific Antibody RO7443904 - Anti-CD28/Anti-CD19 Bispecific Antibody RO7443904 - CD19 x CD28 Bispecific Antibody RO7443904 - RG 6333 - RG-6333 - RG6333 - RO 7443904 - RO-7443904 - RO7443904