Selective Estrogen Receptor Covalent Antagonist TQB3915

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable, selective and covalent antagonist of estrogen receptor alpha (ERalpha; ERa; ESR1; nuclear receptor subfamily 3, group A, member 1; NR3A1), with potential antineoplastic activity. Upon oral administration, selective estrogen receptor covalent antagonist TQB3915 selectively and covalently binds to and inhibits the activity of ERalpha. This inhibits the growth and survival of ERalpha-expressing cancer cells. ERalpha, a nuclear hormone receptor often overexpressed and/or mutated in a variety of cancer cell types, plays a key role in tumor cell proliferation and survival.

**Synonyms:** - TQB 3915 - TQB-3915 - TQB3915