Autologous Anti-CLDN6 CAR-NK Cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous natural killer (NK) cells engineered to express a chimeric antigen receptor (CAR) specific for the cell surface protein claudin 6 (CLDN6), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CLDN6 CAR-NK cells target and bind to CLDN6 expressed on the surface of tumor cells. This induces selective toxicity in tumor cells expressing CLDN6. CLDN6, a tight-junction protein and embryonic antigen, is expressed on a variety of tumor cells but is not expressed on normal, healthy adult cells.

**Synonyms:** - Autologous Anti-CLDN6-CAR-NKs - Autologous CLDN6-CAR-NK Cells - Autologous Claudin 6-targeted CAR-NK Cells