Ipsoprubart

**Semantic type:** Pharmacologic Substance

**Definition:** A human immunoglobulin G1 (IgG1) monoclonal antibody targeting certain specific proteins of the human signal-regulatory protein (SIRP) family, with potential immunoregulatory activity. Upon administration, ipsoprubart targets and binds to SIRP, a cell surface protein expressed on myeloids and T-lymphocytes. This depletes pathological myeloids and T-lymphocytes that are circulating due to excessive immune activation and inflammation. This eradicates pathological immune cells that are driving inflammation. SIRP is a family of cell surface receptors expressed on various immune cell types. Ipsoprubart does not inhibit the activity of the SIRPalpha/CD47 immune checkpoint.

**Synonyms:** - Anti-SIRP Monoclonal Antibody ELA026 - ELA 026 - ELA-026 - ELA026 - IPSOPRUBART - SIRP-directed Monoclonal Antibody ELA026